We want to understand how neurons wire together to form the intricate neural circuits that support complex functions. We address this question in the mouse olfactory system, where uniquely in the mammalian brain, multiple populations of newborn neurons are continuously incorporated into highly ordered circuits throughout life. Taking advantage of its optical accessibility, we can monitor individual newborn neurons and the synaptic connections that they form as they wire into olfactory bulb circuits.

We take a multidisciplinary approach, combining molecular genetic tools, in vivo structural and functional 2-photon imaging, high-resolution anatomical reconstruction, electrophysiology, optogenetics and behavior.